We are developing a system that allows mice to move freely while being exposed to particulate matter (PM) chemical components. This will help us investigate the potential link between PM and Alzheimer’s disease (AD) markers. We are using a state-of-the-art, real-time microdialysis setup and collaborating with Dr. John Cirrito and Dr. Carla Yuede from the WashU School of Medicine to design a mouse model that will enable us to study the effects of controlled PM exposure on AD biomarkers.
